ASK1 anticorps (AA 1356-1375)

N° du produit ABIN1731994

Cet anticorps Lapin Polyclonal détecte spécifiquement ASK1 dans WB, IF, ICC et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour ASK1 anticorps (AA 1356-1375) (ABIN1731994)

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Détail du produit anti-ASK1 anticorps

Épitope: AA 1356-1375

Specificité: Reacts with human ASK1.

Purification: Purified

Immunogène: Synthetic peptide corresponding to aa 1356-1375 of human ASK1. This peptide sequence is different from that of mouse in the last two amino acids

Isotype: IgG

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(0.5 - 1 μg/mL) ICC(10 μg/mL)

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ASK1

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Autre désignation: ASK1

Sujet: A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-jun N-terminal kinase (JNK) and p36 MAP kinase. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death. A catalytically inactive form of ASK1 inhibits TNF -induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.

Mitogen-activated protein kinase kinase kinase 5 Apoptosis signal-regulating kinase 1, ASK-1 MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 Gene name: MAP3K5, ASK1, MAPKKK5, MEKK5

ID gène: 4217

UniProt: Q99683

Pathways: Signalisation MAPK, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response